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Brand name: cozaar
Generic name: Losartan
cozaar description:

Compared with placebo, Cozaar significantly reduced proteinuria by an average of 34%, an effect that was evident within 3 months of starting therapy, and significantly reduced the rate of decline in glomerular filtration rate during the study by 13%, as measured by the reciprocal of the serum creatinine concentration. Of the patients still taking study medication, the mean doses of Cozaar and atenolol were both about 80�mg/day, and 15% were taking atenolol or losartan as monotherapy, while 77% were also receiving hydrochlorothiazide (at a mean dose of 20�mg/day in each group). Cozaar was effective in reducing blood pressure regardless of race, although the effect was somewhat less in Black patients (usually a low-renin population). However, the LIFE study does not provide evidence that the benefits of Cozaar on reducing the risk of cardiovascular events in hypertensive patients with left ventricular hypertrophy apply to Black patients. Cozaar was generally well tolerated as evidenced by a similar incidence of discontinuations due to side effects compared to placebo (19% for Cozaar, 24% for placebo). In the subgroup of Black patients (n=533; 6% of the LIFE study patients), there were 29 primary endpoints among 263 patients on atenolol (11%, 26 per 1000 patient-years) and 46 primary endpoints among 270 patients (17%, 42 per 1000 patient-years) on Cozaar. Treatment with Cozaar resulted in a 16%�risk reduction in this endpoint (see Figure�4 and Table�3). In a clinical study conducted in type�2 diabetic patients with proteinuria, the incidence of hyperkalemia was higher in the group treated with Cozaar as compared to the placebo group; however, few patients discontinued therapy due to hyperkalemia (see ADVERSE REACTIONS). Similar effects have been reported with Cozaar; in some patients, these effects were reversible upon discontinuation of therapy. There were no significant differences in the rates of these endpoints between the Cozaar and atenolol groups.

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